The guys have left the St. Louis area, where they live all though it hasn't directly been referenced in the strip to date...
Due to George's anger at John's numerous stops to pee they have stopped off in a sleepy little town in Illinois.
Also, that's right... Michael Myers wears a Captain Kirk mask. That's a little factoid that won me a bet in highschool that stated my buddy, Andy Triefenbach
from the podcast Destroy the Brain, would owe me a billion dollars. I'm still waiting for said transaction.
There's a coincidence here... he's been trying to sell a Michael Myers mask of his to make some cash. If you're interested in owning your own Myers mask, let him know... Perhaps it'll be the money that puts him over the billion so he can pay me what he owes.